PRAS40 hyperexpression promotes hepatocarcinogenesis
نویسندگان
چکیده
منابع مشابه
PRAS40 signaling in tumor
The proline-rich Akt substrate of 40 kDa (PRAS40) is a substrate of Akt and a component of the mammalian target of rapamycin complex 1 (mTORC1). Locating at the crossroad of the PI3K/Akt pathway and the mTOR pathway, PRAS40 is phosphorylated by growth factors or other stimuli, and regulates the activation of these signaling pathways in turn. PRAS40 plays an important role in metabolic disorders...
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www.landesbioscience.com Cell Cycle 3579 Signals from growth factors, nutrients, energy status, as well as many stressors impinge upon the mechanistic target of rapamycin (mTOR), which exists in 2 distinct complexes, mTORC1 and mTORC2. mTORC1 is rapamycin-sensitive and controls cell size, cell cycle, and metabolism, whereas mTORC2 mediates survival and cytoskeletal organization. Thousands of pu...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2020
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2019.102604